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The Schlessinger lab focuses on the development and application of computational tools to annotate the functions of proteins. The two key areas of research include structure-based drug design for cancer-related membrane transporters and systems pharmacology analysis of complex diseases.

Selected Publications:

  • Schlessinger A, Schaefer C, Vicedo E, Schmidberger M, Punta M, Rost B (2011) Protein disorder–a breakthrough invention of evolution? Curr Opin Struct Biol 21 (3):412-418.
  • Schlessinger A, Geier E, Fan H, Irwin JJ, Shoichet BK, Giacomini KM, Sali A (2011) Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc Natl Acad Sci U S A 108 (38):15810-15815.
  • Geier EG*, Schlessinger A*, Fan H, Gable JE, Irwin JJ, Sali A, Giacomini KM (2013) Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1. Proc Natl Acad Sci U S A 110 (14):5480-5485.
  • Pedersen BP, Kumar H, Waight AB, Risenmay AJ, Roe-Zurz Z, Chau BH, Schlessinger A, Bonomi M, Harries W, Sali A, Johri AK, Stroud RM (2013) Crystal structure of a eukaryotic phosphate transporter. Nature 496 (7446):533-536.
  • Schlessinger A, Yee SW, Sali A, Giacomini KM (2013) SLC classification: an update. Clin Pharmacol Ther. In Press